EpilepsyLive queries Europe PMC and ClinicalTrials.gov live in your browser. Gene list from Genes4Epilepsy (Bahlo Lab). Not medical advice.
EpilepsyLive is a live view of what is being published and trialed across epilepsy genes and epilepsy topics. Nothing is stored on a server. Every list is fetched in your browser when you open the page or change a filter.
EpilepsyLive has three parts, switchable from the bar at the top of every page: this Live Monitor; the Registry Toolkit, a companion demo and guide for rare epilepsy communities planning a research registry, including a searchable comprehensive data dictionary, survey and health-record modules, a maturity model, and self-assessment tools; and PAG Connections, a searchable directory of the advocacy organizations behind each gene, with a network view of how those groups relate.
Publications, preprints, and full text come from Europe PMC. Clinical trials come from ClinicalTrials.gov. Both are queried directly and refresh whenever you change a filter or sort. Known drugs and target evidence on the gene cards come from Open Targets, and the Funders panel comes from Crossref. All four are open, keyless services queried live from your browser.
Europe PMC includes all of PubMed and MEDLINE, plus preprints and open access full text, so PubMed is covered here. The Peer reviewed filter limits results to PubMed and MEDLINE records, and each of those results links out to PubMed.
Genes come from Genes4Epilepsy, a curated set of many monogenic epilepsy genes maintained by the Bahlo Lab. The list is built into the page and refreshed from the source when reachable, so it tracks their twice-yearly updates. Please cite Genes4Epilepsy if you build on it.
With no genes selected, the feed follows the general epilepsy terms you pick. Select or star genes to focus the feed on them. The epilepsy context switch adds an epilepsy filter to gene searches to cut unrelated hits, and can be turned off to see everything mentioning a gene. Any keyword you type is added to the search.
Each result is scanned for epilepsy gene symbols and tagged with the ones it mentions, with featured genes highlighted. Tagging is automated text matching, so treat the tags as a guide rather than a curated annotation.
The Insights tab analyzes your current query and shows the most active authors, linked to ORCID where available; a gene co-occurrence view of which epilepsy genes are studied together, which you can click to focus a gene; a publications-per-year trend; and a Funders panel. It is computed from up to 400 of the most recent matching papers, so it is a representative sample rather than the entire literature. The author table and the full connection table export to CSV. Each row in the gene connection list also has its own Papers link, which opens the papers mentioning both genes on Europe PMC, and an Export button, which downloads a CSV of those papers. Because the co-mention count beside each pair is drawn from the sample, while the Papers link and per-pair export query Europe PMC directly, the numbers you see there reflect the complete matching set under your current filters and may be larger than the sample count. The Funders panel is separate: it queries Crossref for your current selection and lists the funders credited most often, so its coverage depends on the funding metadata that publishers deposited and is independent of the sample and the first-author filter.
You can focus more than one gene at once. Select or star several genes and the insights are built from papers matching any of them, the connection view narrows to pairs that involve your selection, and an identity card appears for each focused gene. Connections are always counted as pairs: each row is two genes mentioned together in the same paper, so a row shows two genes even when you have selected more, and a pair can include a partner gene you did not select because at least one side of the pair is yours. The "US-based first authors only" switch restricts every panel to papers whose first author lists a United States affiliation. That test is text matching on the affiliation string (looking for United States, a state name, or a state and ZIP code), so it is an approximation: some records carry no affiliation and will drop out, and the occasional non-US address can slip through.
Focus a gene and a card appears above the results with its canonical identifiers (HGNC, Ensembl, NCBI Gene, OMIM) and quick links to ClinVar, gnomAD, ClinGen, and Orphanet, drawn from the Genes4Epilepsy record. The card groups the gene's phenotype categories and inheritance mode under labeled rows, with a short key beneath spelling out each abbreviation shown, so their meaning is visible without hovering. Focus several genes and a card appears for each, so you can compare them side by side. Each card also loads known drugs and top associated conditions for the gene from Open Targets, keyed on the Ensembl identifier and fetched live in your browser, with a link out to the full Open Targets target page.
Sort by newest, most cited (using Europe PMC citation counts), or most relevant. Export the loaded list to CSV at any time.
The phenotype and inheritance filters narrow which genes appear in the gene list. They use the categories from the Genes4Epilepsy resource.
EpilepsyLive is for research awareness and is not medical advice. Coverage reflects what the sources index, and results can shift as those sources update.